In 4 research, autologous or allogenic BG was employed: autologous osteochondral calcaneus BG in a single study [36], autologous graft harvested through the ipsilateral talar articular facet in A different study [37], autologous cancellous bone in the distal tibial metaphysis in a third research [38], and also a commercially available and food stuff and Drug Administration-authorised particulated juvenile cartilage allograft transplantation (PJCAT) within a fourth examine [39].
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This matrix, secured from the lesion web-site by fibrin glue, has often been related to the AMIC process given that 1999 to stabilize the super clot along with the lesion immediately after MF, keeping away from the loss of MSCs into the joint Area and, concurrently, assuring the chondrogenic differentiation of these cells [70,71]. Other purely natural matrices utilized by some authors for AMIC were HA-primarily based or hyaluronan types [31,32].
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